Beautystar Causes of recurrent miscarriage include chromosomal defects, uterine defects, and hormone deficiencies.
Chromosomal Abnormalities
Chromosomal abnormalities can be caused by abnormalities that exist in the genetic structure of one or both parents. These abnormalities are not life threatening to the parents, but when passed to the embryo, they can cause miscarriage. Other abnormalities can result during conception and will only exist in the growing embryo. If miscarriage occurs, the cells from the embryo can be tested to determine the existence of abnormalities.
Most usually, chromosomal abnormalities are not treatable. Genetic counseling can offer guidance to couples on the chances of passing abnormalities to their children. Couples can then make informed decisions about continuing to try to conceive using their own eggs and sperm, trying donor eggs or sperm, looking further into adoption, or remaining childless.
Uterine Defects
Defects of the uterus can be caused by several factors. Some women are born with defects in the structure of the uterus caused by genetics or exposure in utero to certain chemicals.
Other defects can be caused by polyps (small growths in the uterine lining) or fibroids, which can cause problems with implantation of the embryo or retard the growth of the fetus, eventually leading to miscarriage.
Uterine defects can be diagnosed using hysterosalpingography, a procedure in which dye is injected into the uterus and then photographed using an X-ray (see Testing and Diagnosis). Treatment may include surgery to go in and reshape the uterus or remove polyps or fibroids.
Hormone Deficiencies
Progesterone is the hormone that is necessary to maintain the pregnancy. If this hormone is not present in sufficient quantities, the pregnancy will abort, sometimes even before it is detected.
This type of hormone deficiency can be treated with supplemental progesterone given during the luteal phase or the first trimester of pregnancy when an inadequate corpus luteum is suspected. Supplemental progesterone is also given during superovulation cycles such as IVF or GIFT to counteract the increased levels of estrogen produced by multiple follicles. Progesterone supplementation is often maintained through the first trimester of these pregnancies to ensure adequate levels.
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